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Vacustyler® Avantgarde Technology: Intermittent Vacuum Therapy (IVT) + Photobiomodulation (PBM) with Red & Near-Infrared Light in Longevity

This scientifically based datasheet describes the combined effects of Intermittent Vacuum Therapy (IVT) and Photobiomodulation (PBM) with red and near-infrared light on the 12 Hallmarks of Aging (according to López-Otín et al.). IVT is based on a physical principle from space medicine: rhythmic alternation between negative and positive pressure phases on the lower extremities promotes microcirculation, vascular function, lymphatic flow, and metabolic activity. PBM uses specific wavelengths (approx. 630–850 nm) to stimulate mitochondrial activity, antioxidant defenses, and regenerative processes.

Mechanisms of IVT

  • Microcirculation & Blood Flow: Increase in capillary diameter, blood flow velocity, and perfusion volume.
  • NO Release: Endothelial production of nitric oxide, improving vascular elasticity.
  • Lymphatic Drainage: Removal of lymphatic load, reduction of edema.
  • Metabolic Optimization: Increased O₂/nutrients, breakdown of metabolites.
  • Neuromodulation: Baroreceptor activation, circulatory regulation.

Mechanisms of PBM (Red & Near-Infrared Light)

  • Mitochondrial Stimulation: Photon activation of cytochrome c oxidase → ATP production ↑.
  • Reduction of Oxidative Stress: ROS decrease, antioxidant enzymes ↑.
  • Inflammation Modulation: Inhibition of pro-inflammatory cytokines (IL-6, TNF-α), promotion of pro-resolving mediators.
  • Collagen & Tissue Regeneration: Activation of fibroblasts, improved wound healing.
  • Neuroprotection: Improved neuronal energy supply and signal transmission.

Synergy Effects IVT + PBM

The patented parallel application in the Vacustyler® Avantgarde combines the hemodynamic advantage of IVT with the cellular photobiomodulation of PBM. While IVT maximizes tissue perfusion and oxygen/nutrient transport, PBM ensures immediate optimization of cellular energy utilization and regeneration. This amplifies effects on several hallmarks simultaneously, particularly in mitochondrial dysfunction, chronic inflammation, and intercellular communication.

Weighted Impact on the 12 Hallmarks of Aging

Hallmark of AgingMechanisms IVT + PBMEvidence Level
Chronic InflammationIVT: Cytokine reduction, lymph activation. PBM: Anti-inflammatory signal modulation.+++++
Altered Intercellular CommunicationIVT: NO release, vascular function ↑. PBM: Cytokine & neurotransmitter modulation.+++++
Mitochondrial DysfunctionIVT: O₂/nutrient supply ↑. PBM: Direct ATP increase, biogenesis signals.+++++
Cellular SenescenceIVT: Inflammation ↓, supply ↑. PBM: SASP reduction, cell vitality ↑.++++
Stem Cell ExhaustionIVT: Perfusion ↑, hypoxia stimulus → mobilization. PBM: Activation & differentiation ↑.++++
MacroautophagyIVT: Promotes homeostasis. PBM: AMPK/sirtuin activation.++++
Nutrient SensingIVT: Nutrient availability ↑. PBM: Metabolic flexibility ↑.++++
Genomic InstabilityIVT: Indirect via stress reduction. PBM: ROS reduction, DNA repair ↑.+++
Telomere AttritionIVT: Indirect protection. PBM: Oxidation protection, telomere stabilization.++
Epigenetic AlterationsIVT: No direct effect. PBM: Redox signal modulation.++
Loss of ProteostasisIVT: No direct effect. PBM: HSP induction, protein folding ↑.++
DysbiosisIVT: Indirect via perfusion. PBM: Indirect via inflammation reduction.++

Evidence Base

IVT has been documented in multiple clinical and preclinical studies for microcirculation enhancement, lymphatic drainage, and endothelial NO release. PBM is evidence-based through numerous studies (RCTs, animal models, in vitro) for mitochondrial stimulation, oxidative stress reduction, anti-inflammatory effects, and tissue regeneration. The combination of both methods leverages complementary mechanisms, addressing more hallmarks simultaneously and more profoundly than single application.

References

  1. Hamblin MR. Mechanisms and applications of the anti-inflammatory effects of photobiomodulation. AIMS Biophys. 2017;4(3):337–361.
  2. Chung H, et al. The Nuts and Bolts of Low-level Laser (Light) Therapy. Ann Biomed Eng. 2012;40(2):516–533.
  3. Salehpour F, et al. Transcranial photobiomodulation therapy: a systematic review of neurocognitive effects in healthy populations. Photobiomodul Photomed Laser Surg. 2019;37(10):587–599.
  4. Ferraresi C, et al. Effects of low-level laser therapy (LLLT) on skeletal muscle: a systematic review. Lasers Med Sci. 2015;30(2):925–939.
  5. Amano T, et al. Photobiomodulation therapy ameliorates insulin resistance by enhancing insulin signaling in skeletal muscle. Sci Rep. 2021;11:353.
  6. Mvula B, et al. The effect of low level laser irradiation on adult mesenchymal stem cells. Lasers Med Sci. 2010;25(3):475–482.
  7. de Freitas LF, Hamblin MR. Proposed mechanisms of photobiomodulation or low-level light therapy. IEEE J Sel Top Quantum Electron. 2016;22(3):7000417.
  8. López-Otín C, et al. The hallmarks of aging. Cell. 2013;153(6):1194–1217.
  9. López-Otín C, et al. Hallmarks of aging: An expanding universe. Cell. 2023;186(2):243–278.
  10. Zhong L, et al. Nitric oxide and vascular function. Curr Hypertens Rep. 2010;12(6):431–436.
  11. Rainer W, et al. Effects of intermittent vacuum therapy on lower limb hemodynamics and microcirculation. Microvasc Res. 2019;124:1–7.
  12. Kern H, et al. Intermittent negative pressure therapy in peripheral artery disease. Vasa. 2011;40(4):291–299.
  13. Thijssen DH, et al. Sympathetic nervous system activation, arterial shear rate, and flow-mediated dilation. J Appl Physiol, 2014.

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